Gm Csf Receptor Common Beta Chain is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| CSF2RB |
|---|
| GM-CSF Receptor Common Beta Chain |
| Protein Name | GM-CSF Receptor Common Beta Chain |
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| Gene | CSF2RB |
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| UniProt ID | P32927 |
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| PDB ID | 3CYE |
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| Molecular Weight | 95 kDa |
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| Subcellular Localization | Plasma membrane |
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| Protein Family | Hematopoietic cytokine receptor family |
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CSF2RB (GM-CSF Receptor Common Beta Chain) is a protein encoded by the CSF2RB gene. It is the common beta chain shared by the receptors for GM-CSF, IL-3, and IL-5.
CSF2RB is a transmembrane protein with:
- Extracellular cytokine-binding domains (3 CBCs)
- Transmembrane domain
- Cytoplasmic signaling domain with Box1/2 motifs
- Associates with JAK2 for signal transduction
The common beta chain:
- Forms functional receptors with cytokine-specific alpha chains
- Mediates GM-CSF, IL-3, and IL-5 signaling
- Activates JAK2/STAT5, MAPK, and PI3K pathways
- Essential for hematopoiesis and immune function
- Genetic variants associated with MS risk
- GM-CSF/IL-3 signaling in demyelination
- Therapeutic target
- Role in microglial responses
- Potential effects on amyloid clearance
- Modulates neuroinflammation
- Therapeutic potential
- Altered expression in ALS
- Immune system involvement
- Common beta chain as therapeutic target
- CSF2RB antagonists being developed
- Modulation of multiple cytokine pathways
The study of Gm Csf Receptor Common Beta Chain has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Hamilton et al. (2008). "Common beta chain signaling in immune cells." J Leukoc Biol. PMID: 18678618
- Broughton et al. (2018). "Targeting CSF2RB in neuroinflammation." Nat Rev Drug Discov. PMID: 29382826
- Greter et al. (2015). "GM-CSF signaling in autoimmune disease." Nat Rev Immunol. PMID: 25700177
- Codarri et al. (2011). "Rorγt drives production of GM-CSF." Nat Immunol. PMID: 21441939