Csf2Rb — Colony Stimulating Factor 2 Receptor Common Beta Chain is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| CSF2RB | |
|---|---|
| Colony Stimulating Factor 2 Receptor Common Beta Chain | |
| Gene Symbol | CSF2RB |
| Full Name | Colony Stimulating Factor 2 Receptor Common Beta Chain |
| Chromosome | 22q12.1 |
| NCBI Gene ID | 1443 |
| Ensembl ID | ENSG00000165178 |
| OMIM | 138981 |
| UniProt ID | P32927 |
| Associated Diseases | Multiple Sclerosis, Alzheimer's Disease, Parkinson's Disease, ALS |
| Expression | Hematopoietic cells, Microglia, Macrophages, Dendritic cells |
CSF2RB (Colony Stimulating Factor 2 Receptor Common Beta Chain) encodes the common beta chain of the high-affinity receptors for GM-CSF, IL-3, and IL-5. This protein is shared by these cytokine receptors and is essential for signal transduction.
The common beta chain mediates signaling for multiple cytokines:
The study of Csf2Rb — Colony Stimulating Factor 2 Receptor Common Beta Chain has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.