Csf1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CSF1 (Colony Stimulating Factor 1), also known as M-CSF (Macrophage Colony-Stimulating Factor), is a hematopoietic growth factor that binds CSF1R to regulate monocyte/macrophage lineage cells, including microglia in the central nervous system. [1]
CSF1 Protein (Colony Stimulating Factor 1), also known as M-CSF (Macrophage Colony-Stimulating Factor), is a homodimeric cytokine that binds to the colony-stimulating factor 1 receptor (CSF1R). It is essential for the survival, proliferation, and differentiation of microglia and macrophages. CSF1 protein is a key therapeutic target for modulating neuroinflammation in Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. [2]
| Property | Value | [3]
|----------|-------| [4]
| Protein Name | Colony Stimulating Factor 1 (CSF1 / M-CSF) | [5]
| Gene | CSF1 | [6]
| UniProt ID | P07333 | [7]
| Molecular Weight | 26-46 kDa (various isoforms) |
| Subcellular Localization | Secreted (soluble and membrane-bound) |
| Protein Family | CSF-1 family |
| Compound | IC50 | Specificity | Status |
|---|---|---|---|
| PLX3397 | 20 nM | CSF1R | Approved (PN) |
| PLX5622 | 9 nM | CSF1R | Research |
| BLZ945 | 1 nM | CSF1R | Preclinical |
The study of Csf1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
CSF1-mediated microglial proliferation in AD models. Glia. ↩︎
CSF1R agonists and antagonists in neurodegeneration. Pharmacology & Therapeutics. ↩︎
CSF1 protein therapeutic applications in MS. Brain Pathology. ↩︎
CSF1 as biomarker for neuroinflammation. Neurology Neuroimmunology Neuroinflammation. ↩︎
CSF1 and amyloid clearance in preclinical models. Journal of Neuroscience. ↩︎
Inhaled CSF1 for PD therapeutic development. Movement Disorders. ↩︎
CSF1 autoantibodies in neurological disorders. Neurology. ↩︎