Crebbp Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CREBBP Protein (CREB-binding protein, also known as CBP) is a transcriptional coactivator with intrinsic histone acetyltransferase (HAT) activity. This critical epigenetic regulator controls gene expression by modifying chromatin structure and interacting with numerous transcription factors, making it essential for learning, memory, and neuronal survival.
| Attribute | Value |
|---|---|
| Protein Name | CREB-binding protein (CBP) |
| Gene | CREBBP |
| UniProt ID | Q92793 |
| Molecular Weight | ~265 kDa |
| Subcellular Localization | Nucleus |
| Protein Family | HAT family (p300/CBP) |
CREBBP contains multiple functional domains:
CREBBP is a master transcriptional regulator:
CREBBP functions through:
Potential therapeutic strategies:
Chan HM, et al. (2001) The role of CREB-binding protein and p300 in nuclear receptor signalling. Nat Rev Mol Cell Biol 2(9):665-673. PMID:11533700
Vecsey CG, et al. (2007) Histone deacetylase inhibitors enhance memory. Nat Rev Neurosci 8(5):355-367. PMID:17499099
Rai M, et al. (2008) CBP and Huntington's disease. Neuron 59(5):681-683. PMID:18786352
Kalkhoven E, et al. (2003) CREBBP and EP300 in gene regulation. Adv Enzyme Regul 43:175-186. PMID:12791385
Levenson JM, et al. (2004) CBP and memory consolidation. Mol Cell 15(5):853-865. PMID:15383276
The study of Crebbp Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Chan HM, et al. The role of CREB-binding protein and p300 in nuclear receptor signalling. Nat Rev Mol Cell Biol 2001;2(9):665-673. PMID:11533700
Vecsey CG, et al. Histone deacetylase inhibitors enhance memory. Nat Rev Neurosci 2007;8(5):355-367. PMID:17499099
Rai M, et al. CBP and Huntington's disease. Neuron 2008;59(5):681-683. PMID:18786352
Kalkhoven E, et al. CREBBP and EP300 in gene regulation. Adv Enzyme Regul 2003;43:175-186. PMID:12791385
Levenson JM, et al. CBP and memory consolidation. Mol Cell 2004;15(5):853-865. PMID:15383276