| Claudin-5 Protein | |
|---|---|
| Protein Name | Claudin-5 Protein |
| Gene | CLDN5 |
| UniProt ID | O00511 |
| Molecular Weight | 21.8 kDa |
| Subcellular Localization | Tight junctions of brain endothelial cells |
| Protein Family | Claudin family |
Claudin 5 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Claudin-5 is a tight junction protein that forms the paracellular barrier of the blood-brain barrier. It is essential for maintaining BBB integrity and preventing leakage of harmful substances into the brain [1].
Claudin-5 is a 218 amino acid protein with:
N-terminus
|
[TM1]-[EC1]-[TM2]-[EC2]-[TM3]-[TM4]
|
C-terminus (PDZ-binding motif)
Claudin-5 is essential for blood-brain barrier function:
Nitta et al., Claudin-5 and BBB integrity (2003). Journal of Cell Biology.
Wolburg et al., Tight junctions of the blood-brain barrier (2009). Neuroscience.
Sweeney et al., Blood-brain barrier breakdown in Alzheimer's disease (2019). Nature Reviews Neurology.
The study of Claudin 5 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S. "Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice." Journal of Cell Biology. 2003;161(3):653-660. DOI:10.1083/jcb.200207055
Wolburg H, Lippoldt A, Ebner B. "Tight junctions of the blood-brain barrier." Progress in Brain Research. 2009;176:39-47. DOI:10.1016/j.neuroscience.2009.02.008
Sweeney MD, Sagare AP, Zlokovic BV. "Blood-brain barrier breakdown in Alzheimer's disease and other neurodegenerative disorders." Nature Reviews Neurology. 2019;15(3):139-151. DOI:10.1038/s41582-019-0167-3