| Cyclin-Dependent Kinase 11 | |
|---|---|
| Protein Name | CDK11 |
| Gene | [CDK11A/B](/genes/cdk11) |
| UniProt | Q9UQ88 |
| Molecular Weight | 110 kDa (full-length), 58 kDa (p58 isoform) |
| Length | 795 amino acids (full-length) |
| Subcellular Localization | Nucleus, Cytoplasm |
| Protein Family | CDK family, CMGC kinase group |
Cdk11 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CDK11 encodes cyclin-dependent kinase 11, a serine/threonine kinase expressed as two isoforms (CDK11A and CDK11B) that are 99% identical at the protein level. CDK11 is unique among CDKs as it is expressed from two separate but highly similar genes. The protein has multiple isoforms generated through alternative translation initiation, including a full-length kinase (p110) and a mitosis-specific isoform (p58).
CDK11 contains the characteristic CDK structure:
CDK11 functions at multiple cell cycle stages:
CDK11 phosphorylates components of:
In neurons, CDK11 regulates:
CDK11 dysregulation is prominent in:
CDK11's functions have implications for:
CDK11 is being explored as a therapeutic target:
The study of Cdk11 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.