| CDK11 — Cyclin-Dependent Kinase 11 | |
|---|---|
| Symbol | CDK11 |
| Full Name | Cyclin-Dependent Kinase 11A/11B |
| Chromosome | 1p36.21 (CDK11A), 1p36.21 (CDK11B) |
| NCBI Gene | 8812 (CDK11A), 983 (CDK11B) |
| Ensembl | ENSG00000049245 |
| UniProt | Q9UQ88 |
| Diseases | Neuroblastoma, Lung Cancer, Various Cancers |
| Expression | Brain, Testis, Lung, Ubiquitous |
Cdk11 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CDK11 encodes a member of the cyclin-dependent kinase (CDK) family that includes two highly similar isoforms: CDK11A and CDK11B. These serine/threonine kinases are involved in the regulation of the cell cycle, RNA processing, and have specific functions in neuronal development and differentiation.
CDK11 is unique among CDKs in that it is expressed from two genes (CDK11A and CDK11B) that produce identical kinases. CDK11 functions at multiple stages of the cell cycle:
In neurons, CDK11 plays important roles in:
CDK11 also phosphorylates components of the:
While not directly a neurodegenerative disease gene, CDK11 dysregulation is seen in:
The cell cycle and RNA processing functions of CDK11 have implications for:
The study of Cdk11 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.