Cerebellin-1 is a Small secreted protein involved in synaptic formation and maintenance, particularly in the cerebellum.
title: Cerebellin-1 Protein [1]
--- [2]
| Property | Value | [3]
|----------|-------| [4]
| Protein Name | Cerebellin-1 | [5]
| Gene | CBLN1 |
| UniProt ID | Q9ULM3 |
| Molecular Weight | ~30 kDa (dimer: ~60 kDa) |
| Subcellular Localization | Secreted, extracellular matrix |
| Protein Family | Cerebellin family |
CBLN1 is a secreted protein that forms homodimers. It contains a conserved cerebellin domain that mediates receptor binding and synaptogenic activity. The protein is secreted and localizes to the synaptic cleft.
CBLN1 is essential for cerebellar synapse formation:
CBLN1 represents a target for:
Last et al. Ataxin-2 function and disease (2020). 2020. ↩︎
Gispert-Sanchez et al. ATXN2 and RNA granules (2015). 2015. ↩︎
Nonis et al. ATXN2 in diabetes (2022). 2022. ↩︎
Kumar et al. ATXN2 therapeutic targeting (2021). 2021. ↩︎