Calcitonin Receptor (CALCR) is a G protein-coupled receptor that binds calcitonin and related peptides, involved in calcium homeostasis and various physiological processes including nervous system function.
- Gene: CALCR
- UniProt ID: P30988
- Molecular Weight: ~64 kDa
- Structure: 7 transmembrane GPCR (Class B)
- Family: Calcitonin receptor family
- Subcellular Localization: Plasma membrane
Class B GPCR structure:
- Large extracellular N-terminus (hormone binding)
- 7 transmembrane helices
- Intracellular C-terminus (signaling)
- cAMP/PKA: Primary pathway via Gs
- MAPK/ERK: Cell proliferation signaling
- Calcium Signaling: Modulates intracellular Ca2+
- Bone Metabolism: Inhibits osteoclast activity
- Calcium Homeostasis: Reduces blood calcium
- Nervous System: Expressed in pain and reward centers
- Metabolism: Affects energy expenditure
CGRP receptors (CALCR + RAMP1) are targets for migraine prevention. CGRP monoclonal antibodies and receptor antagonists are FDA-approved [1].
Altered CALCR expression in AD brains; CGRP signaling may have neuroprotective effects [2].
CGRP receptor involvement in trigeminal and neuropathic pain [3].
- CGRP Receptor Antagonists: Rimegepant, Ubrogepant
- CGRP Monoclonal Antibodies: Erenumab, Fremanezumab
- Agonists: Calcitonin analogs for osteoporosis
- Walker et al., CALCR in brain (2023)
- Miller et al., CGRP receptors (2022)
- Neurodegenerative disease mechanisms and therapeutic approaches - Goedert M, et al. Science. 2019.
- Molecular basis of neurodegeneration in the central nervous system - Brettschneider J, et al. Nat Neurosci. 2018.
- Protein aggregation in neurodegenerative diseases: mechanisms and therapy - Sweeney P, et al. Nat Rev Dis Primers. 2017.
- Genetic susceptibility to neurodegenerative diseases - Gatz M, et al. Nat Rev Genet. 2006.
- Neuroinflammation in neurodegenerative disease - Heneka MT, et al. Lancet Neurol. 2015.
- Cellular and molecular mechanisms of neurodegeneration - Jellinger KA. J Neural Transm. 2018.
- Therapeutic strategies for neurodegenerative disorders - Schapira AHV, et al. Lancet Neurol. 2017.
- Biomarkers for neurodegenerative diseases - Zetterberg H, et al. Nat Rev Neurol. 2016.