Cacng2 Protein Stargazin Calcium Channel Gamma 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CACNG2 (Calcium Channel Gamma-2 Subunit), also known as stargazin, is a gamma subunit of voltage-gated calcium channels. Beyond its role in calcium channels, stargazin is renowned for its critical function in AMPA receptor trafficking, making it essential for synaptic plasticity and excitatory neurotransmission. [1]
| Property | Value | [2]
|----------|-------| [3]
| Protein Name | Voltage-gated calcium channel gamma-2 subunit (Stargazin) |
| Gene Symbol | CACNG2 |
| UniProt ID | Q9Y698 |
| Molecular Weight | ~41 kDa |
| Protein Length | 366 amino acids |
| Chromosomal Location | 22q12.3 |
The CACNG2/stargazin protein has a unique structure:
| Strategy | Agent | Status |
|---|---|---|
| Ampakines | CX516, CX1739 | Clinical trials |
| PSD-95 Modulators | - | Research |
| Gene Therapy | AAV-stargazin | Experimental |
The study of Cacng2 Protein Stargazin Calcium Channel Gamma 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.