Cacnb1 Protein Calcium Channel Beta 1 Subunit is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CACNB1 (Calcium Channel Beta-1 Subunit) is the beta-1 auxiliary subunit of voltage-gated calcium channels (VGCCs). This protein plays a critical role in modulating the trafficking, gating, and functional expression of calcium channel complexes in various tissues including the brain and heart. [1]
| Property | Value | [2]
|----------|-------|
| Protein Name | Voltage-gated calcium channel subunit beta-1 |
| Gene Symbol | CACNB1 |
| UniProt ID | Q14816 |
| Molecular Weight | ~65 kDa |
| Protein Length | 597 amino acids |
| Chromosomal Location | 17q22 |
The CACNB1 protein contains several functional domains:
| Strategy | Agent | Status |
|---|---|---|
| Calcium Channel Blockers | Various | Approved |
| Beta Subunit Modulators | - | Research |
| Gene Therapy | AAV vectors | Experimental |
The study of Cacnb1 Protein Calcium Channel Beta 1 Subunit has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.