Bk Channel Alpha Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
BK (Slo1) is a large-conductance voltage and calcium-activated potassium channel. It regulates neuronal firing, muscle contraction, and hormone secretion. BK channels have seven transmembrane domains and a large cytosolicregulatory domain.
BK Channel Alpha Protein is encoded by the KCA1A gene. It is a Large conductance voltage and calcium-activated potassium channel. The UniProt ID is Q12790.
BK (Slo1) is a large-conductance voltage and calcium-activated potassium channel. It regulates neuronal firing, muscle contraction, and hormone secretion. BK channels have seven transmembrane domains and a large cytosolicregulatory domain.
The protein is expressed in Plasma membrane, Mitochondria and plays important roles in cellular physiology.
BK channel mutations cause ataxia and epilepsy. BK channel dysfunction contributes to neurodegenerative processes.
BK channel openers (e.g., BMS-204352) have been investigated for stroke and neurodegenerative diseases.
The study of Bk Channel Alpha Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.