Actinin Alpha 2 (Actn2 Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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ACTN2 Protein
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Protein Name: Actinin Alpha 2
Gene: ACTN2
UniProt ID: P35609
Molecular Weight: 103 kDa
Protein Family: Spectrin superfamily
Subcellular Localization: Cytoskeleton, postsynaptic
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Actinin Alpha 2 is a protein encoded by the ACTN2 gene. It belongs to the Spectrin superfamily and is primarily localized to Cytoskeleton, postsynaptic.
ACTN2 is a 103 kDa protein with multiple domains that enable its scaffolding and signaling functions in neurons.
Actin binding, synaptic organization, spine morphology. This protein plays important roles in maintaining normal neuronal function and synaptic transmission.
Alterations in ACTN2 have been associated with several neurodegenerative and neurological disorders. Studies have shown changes in expression and mutations in various disease contexts.
Research is ongoing to develop therapeutic approaches targeting ACTN2 for neurological disorders.
[1] https://pubmed.ncbi.nlm.nih.gov/10574462/
[2] https://pubmed.ncbi.nlm.nih.gov/10893236/
[3] https://pubmed.ncbi.nlm.nih.gov/11891228/
[4] https://pubmed.ncbi.nlm.nih.gov/15231748/
[5] https://pubmed.ncbi.nlm.nih.gov/19139271/
Alpha-actinin is an F-actin crosslinking protein with crucial roles in:
The study of Actinin Alpha 2 (Actn2 Protein) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.