| P-glycoprotein (ABCB1) | |
|---|---|
| Protein Name | P-glycoprotein (ABCB1) |
| Gene | ABCB1 |
| UniProt ID | P08183 |
| Molecular Weight | 170 kDa |
| Subcellular Localization | Plasma membrane of brain endothelial cells |
| Protein Family | ABC transporter family (ABCB/MDR/TAP subfamily) |
P Glycoprotein (Abcb1) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
P-glycoprotein (ABCB1) is an ATP-dependent efflux transporter that pumps drugs and toxins out of cells. At the blood-brain barrier, it prevents many therapeutic drugs from entering the brain, limiting treatment options for neurological diseases [1].
ABCB1 is a 1280 amino acid protein with:
[TM1-6]----[NBD1]----[TM7-12]----[NBD2]
Each TMD: 6 transmembrane helices
Each NBD: Walker A/B motifs for ATP binding
ABCB1 uses the energy from ATP hydrolysis to transport substrates:
ABCB1 is the main efflux transporter at the BBB:
Löscher & Potschka, Blood-brain barrier ABC transporters (2005). Trends in Pharmacological Sciences.
Schinkel, P-glycoprotein (1999). Nature Medicine.
Pardridge, Blood-brain barrier drug delivery (2019). Nature Reviews Neurology.
The study of P Glycoprotein (Abcb1) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Löscher W, Potschka H. "Blood-brain barrier ABC efflux transporters: efflux mechanisms and emerging therapeutic applications." Trends in Pharmacological Sciences. 2005;26(9):502-511. DOI:10.1016/j.tips.2005.07.004
Schinkel AH. "P-glycoprotein, a gatekeeper in the blood-brain barrier." Advanced Drug Delivery Reviews. 1999;36(2-3):179-194. DOI:10.1016/S0169-409X(98)00085-4
Pardridge WM. "Blood-brain barrier drug delivery." Nature Reviews Neurology. 2019;15(9):549-562. DOI:10.1038/s41582-019-0182-4