| Alpha-1 Antitrypsin (SERPINA1) | |
|---|---|
| Gene | SERPINA1 |
| UniProt | P01009 |
| PDB | 5O31 |
| Mol. Weight | 46 kDa |
| Localization | Secreted, extracellular |
| Family | Serpin family |
| Diseases | [Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease) |
Alpha-1 Antitrypsin (SERPINA1) is a protein encoded by the SERPINA1 gene. It belongs to the Serpin family family and has a molecular weight of approximately 46 kDa. This protein is localized to Secreted, extracellular and plays a significant role in the pathogenesis of Alzheimer's Disease, Parkinson's Disease.
Alpha-1 Antitrypsin (SERPINA1) has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: 5O31.
The protein's three-dimensional structure can also be explored via the AlphaFold Protein Structure Database.
Under physiological conditions, Alpha-1 Antitrypsin (SERPINA1) performs essential functions in the nervous system. It is primarily found in Secreted, extracellular and contributes to normal cellular homeostasis, signaling, and neuronal function.
Alpha-1 Antitrypsin (SERPINA1) is implicated in the following neurodegenerative conditions:
Misfolding, aggregation, or dysfunction of Alpha-1 Antitrypsin (SERPINA1) contributes to neuronal damage through various mechanisms including proteotoxic stress, disrupted cellular signaling, and neuroinflammation.
Alpha-1 Antitrypsin (SERPINA1) represents an important therapeutic target. Multiple drug development programs are exploring strategies to modulate its function, reduce toxic forms, or enhance clearance mechanisms.