Mitochondrial quality control (MQC) encompasses the molecular and organellar systems that preserve mitochondrial integrity, including proteostasis, dynamics, mitophagy, biogenesis, and stress signaling.[1][2] Neurons are especially dependent on MQC because of their high energetic demand and long-lived architecture.
MQC failure promotes bioenergetic collapse, reactive oxygen stress, calcium dysregulation, and defective organelle turnover across multiple neurodegenerative diseases.[1:1][2:1] Genetic links in Parkinson's disease, Huntington's disease, and ALS have reinforced MQC as a common vulnerability node.
Mitochondrial quality control in neurodegenerative diseases. Biochimie (2014). ↩︎ ↩︎
Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease. Frontiers in Neuroscience (2018). ↩︎ ↩︎