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| Location |
New York, NY, USA |
| Type |
Medical School |
| Website |
https://icahn.mssm.edu/ |
| Focus Areas |
[Alzheimer's Disease](//alzheimers), Genomics, Systems Biology |
| Departments |
Department of Neuroscience
Alzheimer's Disease Research Center |
Icahn School of Medicine at Mount Sinai is a premier medical school and research institution located in New York, NY, USA. Mount Sinai has established itself as a leader in applying genomics and systems biology approaches to understand neurodegenerative . The institution's unique strength lies in integrating large-scale genomic data with clinical research to identify novel therapeutic targets.
The institution hosts 3 researchers tracked in the NeuroWiki database and maintains 2 departments dedicated to neuroscience research^2]. The research programs span Alzheimer's Disease, Genomics, and Systems Biology, contributing to both basic science understanding and translational approaches for neurodegenerative conditions.
¶ History and Milestones
Mount Sinai's journey in neuroscience has been marked by innovation in genomics and translational research.
Key Historical Milestones:
- 1963: Mount Sinai School of Medicine established
- 1990s: Pioneering work in brain banking and neuropathology
- 2000s: Leadership in genome-wide association studies (GWAS)
- 2012: Department of Neuroscience established
- 2015: NIH-funded Alzheimer's Disease Research Center
- 2020: Single-cell genomics in neurodegeneration
¶ Departments and Centers
- Department of Neuroscience: Comprehensive neuroscience research
- Alzheimer's Disease Research Center: NIH-funded clinical research
- Center for Alzheimer's Disease Research: Translation-focused program
- GWAS: Large-scale genetic studies in AD and PD
- Whole Exome/Genome Sequencing: Rare variant discovery
- Epigenomics: DNA methylation and chromatin states
- Multi-Omics Integration: Combining genomics, transcriptomics, proteomics
- Network Analysis: Protein-protein interaction networks
- Systems Pharmacology: Computational drug discovery
- Genetic risk scores
- Blood-based
- Multi-modal
¶ Notable Discoveries and Contributions
- AD GWAS: Identification of novel risk genes (CLU, PICALM, CR1)
- TREM2: Validation of TREM2 variants in AD risk
- APOE: Fine-mapping of APOE region
- Mount Sinai Brain Bank: Comprehensive molecular profiling
- Accelerating Medicines Partnership: AD biomarker discovery
- Single-Cell Atlas: Cell-type specific changes in AD
- Novel target identification through genomics
- Systems pharmacology approaches
- Repositioning of existing drugs
| Researcher |
Focus Areas |
| Alison Goate |
Genetics, AD |
| Bin Zhang |
Systems Biology, Multi-omics |
| Vahram Haroutunian |
Neuropathology, Genomics |
¶ Funding and Resources
- NIH ADRC (P50)
- R01 grants in genomics and systems biology
- Foundation grants (Alzheimer's Association, Michael J. Fox)
- Genomics Core: Next-generation sequencing
- Bioinformatics Core: Computational resources
- Human Brain Bank: Extensive tissue collection
- Clinical Research Unit: Patient recruitment
Mount Sinai provides comprehensive clinical care through:
- Memory disorders clinic
- Movement disorders program
- Clinical trials unit
- Caregiver support services
- Karch et al., Nature Reviews Neurology (2022) - Genetics of AD
- Chen et al., Cell (2020) - Multi-omics of AD
Mount Sinai leads international genomics efforts:
- AMP-AD: Accelerating Medicines Partnership
- International Genomics Consortium
- Global Alliance for Genomics and Health
- Single-cell analysis: Cell-type resolution
- Systems pharmacology: Computational drug discovery
- Immunotherapy: Novel antibody approaches
- Translate genomics to therapy
- Multi-omics integration
- Clinical validation
¶ Impact and Recognition
- Major genetic discoveries in AD
- Novel therapeutic targets
- Training future leaders
- Sequencing Core: Whole genome/exome
- Genotyping: GWAS support
- Single-Cell: Cell atlas generation
- Computational Cluster: Analysis
- Data Science Team: Support
- Machine Learning: AI/ML
- MRI: 3T and 7T scanners
- PET: Molecular imaging
- Microscopy: Advanced imaging
- PhD in Biomedical Sciences: Doctoral
- Master's Programs: Research and clinical
- Neurology Residency: Training
- Fellowships: Sub-specialty
- Research Training: K12 programs
¶ Genomics and Genetics
Mount Sinai is a leader in AD genetics:
- GWAS: Large-scale genetic association studies
- Whole Exome Sequencing: Rare variant discovery
- Functional Genomics: Understanding variant effects
- Genetic Risk Scores: Polygenic risk prediction
Research into genetic contributors to PD:
- LRRK2: Common genetic risk factor
- GBA: Glucocerebrosidase gene associations
- SNCA: Alpha-synuclein genetics
- Novel Genes: New genetic discoveries
- Whole Genome Sequencing: Comprehensive variant detection
- RNA Sequencing: Gene expression analysis
- Epigenomics: DNA methylation and chromatin states
- Mass Spectrometry: Protein quantification
- Phosphoproteomics: Signaling pathways
- Proteomics Atlas: Protein expression across brain regions
- Metabolite Profiling: Metabolic changes in disease
- Lipidomics: Membrane lipid alterations
- Integration: Multi-omics integration
Comprehensive care:
- Diagnostic Evaluation: Thorough assessment
- Treatment Options: Current therapies
- Clinical Trials: Access to new treatments
- Caregiver Support: Education and resources
Expert Parkinson's care:
- Medication Management: Optimizing treatment
- Surgical Options: DBS evaluation
- Rehabilitation: Comprehensive therapy
- Research: Clinical trials
- PhD in Biomedical Sciences: Doctoral training
- MD/PhD Program: Combined degrees
- Master's Programs: Specialized training
- Neurology Residency: ACGME program
- Memory Disorders Fellowship: Sub-specialty
- Movement Disorders Fellowship: Advanced training
- Genetic Stratification: Based on genotype
- Biomarker-Guided: Personalized treatment
- Targeted Therapies: Disease-specific approaches
- AI Drug Discovery: Machine learning approaches
- Network Analysis: Systems biology
- Predictive Models: Disease progression
- Accelerating Medicines Partnership
- UK Biobank
- Human Cell Atlas
- Whole Genome Sequencing
- Single-Cell RNA Sequencing
- Bioinformatics Analysis
- NIH
- Alzheimer's Association
- Michael J. Fox Foundation