This index contains 775 unique research hypotheses extracted from SEA-AD (Seattle-Alzheimer's Disease Brain Cell Atlas) publications using LLM-assisted extraction.
The hypotheses were extracted using a 4-pass pipeline:
| Category | Count |
|---|---|
| Total Hypotheses | 775 |
| Established | 61 |
| Supported | 443 |
| Proposed | 147 |
| Speculative | 117 |
Here are some example hypothesis pages created from the extraction:
| Hypothesis | Type | Confidence | Diseases |
|---|---|---|---|
| Alterations in intra-regional functional connectiv... | Disease Model | Supported | Mild Cognitive Impairment (MCI), cognitive decline |
| Both left and right medial temporal lobes (MTL) ar... | Therapeutic Hypothesis | Supported | Mild Cognitive Impairment (MCI), cognitive decline |
| The k-cardinality tree (KCT) network optimization ... | Mechanistic Proposal | Supported | Alzheimer's Disease, MCI |
| Tree-like propagation pathways represent the criti... | Mechanistic Proposal | Proposed | Alzheimer's Disease, cognitive decline |
| Intra-regional connectivity analysis within DMN re... | Conjecture | Speculative | Alzheimer's Disease, aging |
| Declining functional connectivity of the DMN may b... | Disease Model | Established | Alzheimer's Disease, prodromal AD |
| The unique composition of the telencephalon's olig... | Disease Model | Speculative | multiple sclerosis |
| Deeper sampling in mouse brain would reveal simila... | Conjecture | Speculative | |
| The complexity of splatter neurons reflects under-... | Mechanistic Proposal | Supported | |
| GABAergic neurons in parabrachial nuclei may origi... | Causal Chain | Supported |
The hypotheses were extracted using a systematic LLM-based pipeline: