Slc2A4 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Slc2A4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [1]
.infobox-gene [2]
!! colspan="2" style="background:#f8f9fa; text-align:center; font-weight:bold" | SLC2A4 - Solute Carrier Family 2 Member 4 (GLUT4) [3]
|- [4]
! Chromosomal Location [5]
| 17p13 [6]
|- [7]
! NCBI Gene ID
! OMIM
! Ensembl ID
! UniProt
! Associated Diseases
| Insulin resistance, Diabetes |
|---|
SLC2A4 encodes GLUT4, an insulin-responsive glucose transporter. While primarily studied in muscle and fat, it is also expressed in certain brain regions and may play a role in hypothalamic glucose sensing.
Insulin resistance, Diabetes
Expressed in skeletal muscle, heart, adipose tissue, and brain (hypothalamus).
Slc2A4 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Slc2A4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
: Kandasamy P, et al. SLC transporters as therapeutic targets. 2020. ↩︎
: Hediger MA, et al. The ABCs of solute carriers: physiological, pathological and therapeutic implications. 2004. ↩︎
: Goncalves P, et al. Glucose transporters in the mammalian blood-brain barrier. 2013. ↩︎
: Shental-Bechor D, et al. Neurotransmitter transporters: structure, function, and disease. 2007. ↩︎
: Verrey F, et al. Cross-species analysis of plasma membrane calcium-dependent ATPases (PMCAs). 2003. ↩︎
: Palacin M, et al. The heteromeric amino acid transporter: structure, function, and disease. 2005. ↩︎
: Amara SG, et al. Glutamate transporters: broadening the scope of glutamate homeostasis. 2002. ↩︎