Sirpa Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | SIRPA |
|---|---|
| Full Name | signal regulatory protein alpha |
| Chromosomal Location | 20p13 |
| NCBI Gene ID | [https://www.ncbi.nlm.nih.gov/gene/10388 10388] |
| OMIM | [https://www.omim.org/entry/602463 602463] |
| Ensembl ID | ENSG00000198053 |
| UniProt ID | [https://www.uniprot.org/uniprot/P78324 P78324] |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimer-disease), [Neuroinflammation](/diseases/neuroinflammation), [Stroke](/diseases/stroke) |
SIRPA (Signal Regulatory Protein Alpha) is a transmembrane protein that primarily expressed on macrophages, dendritic cells, and neurons. It is the receptor for CD47 and plays a critical role in the "don't eat me" signaling pathway.
SIRPA is expressed in:
The study of Sirpa Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The SIRPA Gene is involved in various cellular processes in the nervous system. This entity plays important roles in gene expression regulation, cellular signaling, and homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
The SIRPA Gene participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis.
Alterations in SIRPA Gene expression or function have been associated with several neurodegenerative conditions. Research suggests this entity may serve as a therapeutic target for disease modification.