Cd47 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | CD47 |
|---|---|
| Full Name | CD47 molecule |
| Chromosomal Location | 3q13.12 |
| NCBI Gene ID | [https://www.ncbi.nlm.nih.gov/gene/961 961] |
| OMIM | [https://www.omim.org/entry/604258 604258] |
| Ensembl ID | ENSG00000196776 |
| UniProt ID | [https://www.uniprot.org/uniprot/Q08722 Q08722] |
| Associated Diseases | [Alzheimer's Disease](/diseases/alzheimer-disease), [Multiple Sclerosis](/diseases/multiple-sclerosis), [Stroke](/diseases/stroke) |
CD47 is a transmembrane protein that acts as a "don't eat me" signal by binding to SIRPα on macrophages and other phagocytic cells. It is a critical immune checkpoint that prevents excessive phagocytosis.
CD47 is ubiquitously expressed:
The study of Cd47 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The CD47 Gene is involved in various cellular processes in the nervous system. This entity plays important roles in gene expression regulation, cellular signaling, and homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.
The CD47 Gene participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to cellular signaling, gene regulation, and homeostasis.
Alterations in CD47 Gene expression or function have been associated with several neurodegenerative conditions. Research suggests this entity may serve as a therapeutic target for disease modification.