Rtn4 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Rtn4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
RTN4 (Reticulon 4), also known as Nogo-B, is the most ubiquitously expressed member of the reticulon family. While RTN2 (Nogo-A) is neuron-specific, RTN4 isoforms are found throughout the body, with important roles in ER function, vascular development, and immune responses.
| Property | Value |
|---|---|
| Gene Symbol | RTN4 |
| Full Name | Reticulon 4 (Nogo-B) |
| Chromosomal Location | 22q11.21 |
| NCBI Gene ID | 57142 |
| OMIM | 604569 |
| Ensembl ID | ENSG00000145113 |
| UniProt | Q9NPD4 |
| Associated Diseases | Schizophrenia, Stroke, Multiple Sclerosis |
RTN4 has multiple isoforms with diverse functions:
RTN4 is expressed in:
Title: Nogo-B: a novel therapeutic target for vascular disease?
Authors:ace N, et al.
Journal: Nature Reviews Cardiology
Year: 2019
[DOI:10.1038/s41569-019-0198-3](https://doi.org/10.1038/s41569-019-0198-3)
Title: Reticulon 4 in neurological disorders
Authors: Pernet V, Schwab ME
Journal: Current Opinion in Neurology
Year: 2012
[DOI:10.1097/WCO.0b013e32834f0334](https://doi.org/10.1097/WCO.0b013e32834f0334)
Rtn4 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Rtn4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.