Rpl23 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Full Name | Ribosomal Protein L23 |
|---|---|
| Chromosomal Location | 17q21.31 |
| NCBI Gene ID | 9349 |
| OMIM | 604563 |
| Ensembl ID | ENSG00000125691 |
| UniProt ID | P62829 |
| Associated Diseases | Diamond-Blackfan Anemia |
This gene encodes a ribosomal protein component of the 40S ribosomal subunit. Ribosomal proteins are essential for protein synthesis and have been implicated in various neurological conditions.
RPL23 is a component of the 60S ribosomal subunit. It is involved in protein synthesis and has been studied for its role in cell proliferation and cancer. RPL23 can inhibit MDM2 and activate p53 in response to ribosomal stress.
RPL23 is ubiquitously expressed with high expression in proliferating cells, bone marrow, and brain tissue.
The study of Rpl23 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.