PPP2R1A encodes the regulatory subunit A alpha of protein phosphatase 2A (PP2A), a major serine/threonine phosphatase in the brain. PP2A is crucial for tau dephosphorylation, and its dysfunction is implicated in Alzheimer's disease and other tauopathies. [1]
PPP2R1A (Protein Phosphatase 2 Regulatory Subunit A Alpha) encodes the alpha isoform of the structural/regulatory subunit A of PP2A. PP2A is one of the most abundant protein phosphatases in eukaryotic cells and plays essential roles in regulating various cellular processes, including signal transduction, cell cycle progression, and tau phosphorylation dynamics in neurons.
| Property | Value |
|---|---|
| Gene Symbol | PPP2R1A |
| Full Name | Protein Phosphatase 2 Regulatory Subunit A Alpha |
| Chromosomal Location | 19q13.41 |
| NCBI Gene ID | 5518 |
| OMIM ID | 616981 |
| Ensembl ID | ENSG00000101162 |
| UniProt ID | P46821 |
| Encoded Protein | PP2A subunit A (PR65-alpha) |
| Associated Diseases | Alzheimer's disease, breast cancer, tauopathies |
PPP2R1A encodes the alpha isoform of the PP2A subunit A, which serves as a scaffold for assembling the PP2A holoenzyme.
Key normal physiological functions include:
PP2A dysfunction is a hallmark of AD:
PPP2R1A exhibits widespread expression:
The study of Ppp2R1A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Xu Y, et al. PP2A activator for AD therapy. 2020. ↩︎