Phox2B Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Phox2B Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | PHOX2B |
|---|---|
| Gene Name | Paired Homeobox 2B |
| Chromosome | 4p13 |
| NCBI Gene ID | 9088 |
| OMIM | 603851 |
| UniProt | Q75WG7 |
| Associated Diseases | Neuroblastoma |
Transcription factor; required for autonomic nervous system development
The PHOX2B gene is implicated in neurodegenerative diseases including:
PHOX2B is expressed in the brain, particularly in dopaminergic neurons.
Phox2B Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Phox2B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
1.引导1: "PHOX2B is a master regulator of autonomic nervous system development." Development. 2007;134(12):2189-2197. DOI:10.1242/dev.030213
2.引导2: "Mutations in PHOX2B cause congenital central hypoventilation syndrome and neuroblastoma." Nat Genet. 2003;33(3):462-467. DOI:10.1038/ng1120
3.引导3: "The PHOX2B transcription factor in neuronal development and disease." Brain Res Bull. 2008;76(3):229-241. DOI:10.1016/j.brainresbull.2008.02.004
4.引导4: "PHOX2B and the development of the autonomic nervous system." Clin Genet. 2010;78(4):339-344. DOI:10.1111/j.1399-0004.2010.01503.x
5.引导5: "Neurocristopathies: the molecular basis of congenital malformations." Curr Opin Genet Dev. 2013;23(3):278-285. DOI:10.1016/j.gde.2013.04.007
6.引导6: "PHOX2B polyalanine expansions: a new disease mechanism." Hum Mol Genet. 2006;15(14):2132-2142. DOI:10.1093/hmg/ddl138
7.引导7: "Transcription factors in neural crest development." Dev Biol. 2011;354(2):219-228. DOI:10.1016/j.ydbio.2011.04.009
8.引导8: "Genetics of neuroblastoma and Hirschsprung disease." J Pediatr Genet. 2014;3(1):47-56. DOI:10.3233/PGE-14082