Ndufaf5 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Ndufaf5 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| NADH Dehydrogenase Complex Assembly Factor 5 | |
|---|---|
| Gene Symbol | NDUFAF5 |
| Full Name | NADH Dehydrogenase Complex Assembly Factor 5 |
| Chromosome | 20p12.1 |
| NCBI Gene ID | 79776 |
| OMIM | 612360 |
| Ensembl ID | ENSG00000120738 |
| UniProt ID | Q9NYY8 |
| Associated Diseases | Leigh Syndrome, Mitochondrial Complex I Deficiency |
NDUFAF5 encodes a mitochondrial complex I assembly factor with a sulfurtransferase domain. The protein is required for the incorporation of iron-sulfur clusters into complex I subunits.
Expressed in tissues with high mitochondrial energy demands.
| Disease | Role | Mechanism |
|---|---|---|
| Leigh Syndrome | Causative | Impaired iron-sulfur cluster assembly |
Ndufaf5 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Ndufaf5 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.