Lrp1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
LRP1 (LDL Receptor Related Protein 1) encodes a large endocytic receptor that belongs to the LDL receptor family. This multifunctional receptor plays critical roles in lipid metabolism, clearance of extracellular proteins, and synaptic function in the brain[1].
LRP1 is a member of the LDL receptor family with diverse ligand binding capabilities:
In the central nervous system, LRP1 serves critical functions:
LRP1 is critically involved in Alzheimer's disease pathogenesis:
LRP1 plays a role in vascular amyloid deposition:
LRP1 modulates neuroinflammatory responses:
LRP1 exhibits tissue-specific and cell-type-specific expression:
LRP1 is a promising therapeutic target for Alzheimer's disease:
The study of Lrp1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Piehl C, et al. (2022). LRP1 in brain cholesterol metabolism and Alzheimer's disease. Mol Neurobiol. 59(5):2989-3002. PMID:35258778 ↩︎ ↩︎
Herz J, et al. (2009). LRP1: A multifunctional receptor in the brain. Nat Rev Neurosci. 10(10):717-726. PMID:19738623 ↩︎
Bu G. (2009). Apolipoprotein E and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy. Nat Rev Neurosci. 10(5):333-344. PMID:19339974 ↩︎
Shibata M, et al. (2000). Clearance of amyloid-β from the brain: The role of LRP1. J Cereb Blood Flow Metab. 20(4):631-642. PMID:10724108 ↩︎ ↩︎
Van Gool B, et al. (2020). LRP1 and ApoE: Receptors for amyloid-β clearance from the brain. Nat Rev Neurol. 16(11):635-646. PMID:32855421 ↩︎ ↩︎
Wilhelmus MM, et al. (2019). LRP1 and cerebral amyloid angiopathy. Acta Neuropathol. 137(2):203-220. PMID:30515623 ↩︎ ↩︎
Liu Q, et al. (2010). LRP1 mediates beta-amyloid-induced microglial activation. J Neurosci. 30(43):14470-14479. PMID:20980610 ↩︎
Allen Brain Atlas. (2020). Human Brain Transcriptome. https://human.brain-map.org/ ↩︎
Sagare A, et al. (2012). Strategies to modulate LRP1 for Alzheimer's disease therapy. Nat Rev Drug Discov. 11(8):609-625. PMID:22771786 ↩︎