| KEAP1 — Kelch-Like ECH-Associated Protein 1 | |
|---|---|
| Symbol | KEAP1 |
| Full Name | Kelch-Like ECH-Associated Protein 1 |
| Chromosome | 19p13.2 |
| NCBI Gene | 9817 |
| Ensembl | ENSG00000179943 |
| OMIM | 606080 |
| UniProt | Q14145 |
| Diseases | Neurodegeneration, Cancer, Pulmonary Fibrosis |
| Expression | Ubiquitous - High in brain, lung, liver |
Keap1 — Kelch Like Ech Associated Protein 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KEAP1 (Kelch-Like ECH-Associated Protein 1) is a gene located on chromosome 19p13.2 that encodes a cysteine-rich protein that serves as the primary sensor for oxidative stress. KEAP1 is the key regulator of the Nrf2 transcription factor, which controls the cellular antioxidant response.1
The gene is catalogued as NCBI Gene ID 9817.
KEAP1 is a adaptor protein that sequesters Nrf2 in the cytoplasm under basal conditions:
KEAP1 contains multiple cysteine residues that sense oxidative stress:
When oxidative stress occurs, cysteines are modified, leading to Nrf2 release.
KEAP1 is ubiquitously expressed:
KEAP1-Nrf2 pathway is crucial in neurodegeneration:
The study of Keap1 — Kelch Like Ech Associated Protein 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Page auto-generated from NeuroWiki gene database.