KDM3A (Lysine Demethylase 3A), also known as JHDM2A or JMJD1A, is a histone demethylase that removes methyl groups from histone H3 at lysine 9 (H3K9). This enzyme is involved in transcriptional regulation, metabolism, and stress responses.
| Property |
Value |
| Gene Symbol |
KDM3A |
| Gene Name |
Lysine Demethylase 3A |
| Aliases |
JHDM2A, JMJD1A, TSGA |
| Chromosomal Location |
2p11.2 |
| NCBI Gene ID |
55630 |
| OMIM |
607442 |
| UniProt |
Q9N3T2 |
| Ensembl |
ENSG00000188290 |
KDM3A is a Jumonji C domain-containing demethylase:
Demethylates:
- H3K9me2 (primary)
- H3K9me1
- H3K9me3 (weaker)
Enzyme activity is regulated by:
- Oxygen availability
- Cellular metabolites
- Post-translational modifications
KDM3A regulates gene expression:
- Activates transcription through H3K9 demethylation
- Regulates hormone-responsive genes
- Modulates metabolic gene expression
Involved in metabolic regulation:
- Adipogenesis
- Lipid metabolism
- Mitochondrial function
Essential for male fertility:
- Regulates testis-specific gene expression
- Required for normal sperm development
Part of hypoxia-inducible factor (HIF) pathway:
- Regulates HIF target genes
- Adaptation to low oxygen
KDM3A dysregulation in:
- Prostate cancer
- Breast cancer
- Renal cell carcinoma
- Testicular germ cell tumors
Potential involvement in:
- Obesity
- Type 2 diabetes
- Fatty liver disease
KDM3A is a H3K9 demethylase with roles in transcription, metabolism, spermatogenesis, and hypoxia response.
- Takahashi et al., JHDM2A is a histone demethylase regulating chromatin dynamics (2007)
- Kooistra et al., KDM3A (JHDM2A) in transcriptional activation (2012)
- Kim et al., KDM3A regulates gene expression in neuronal development (2019)
- Cheng et al., Histone demethylases in neurodevelopment (2019)
- Zhou et al., JHDM2A/KDM3A in metabolic regulation and brain function (2020)
- Inoue et al., Histone demethylases and neuronal plasticity (2018)
- Watarai et al., KDM3A is required for male germ cell development (2010)
- Liu et al., KDM3A regulates neural differentiation via histone demethylation (2021)
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