Kcna5 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
KCNA5 (Potassium Voltage-Gated Channel Subfamily A Member 5) encodes the Kv1.5 subunit, a voltage-gated potassium channel that contributes to the delayed rectifier potassium current in cardiac and neuronal tissues. Located on chromosome 12p13, KCNA5 encodes a protein of 611 amino acids.
| Property |
Value |
| Gene Symbol |
KCNA5 |
| Full Name |
Potassium Voltage-Gated Channel Subfamily A Member 5 |
| Chromosomal Location |
12p13.31 |
| NCBI Gene ID |
3746 |
| OMIM ID |
176268 |
| Ensembl ID |
ENSG00000130037 |
| UniProt ID |
P22460 |
The Kv1.5 protein contains:
- Six transmembrane helices (S1-S6)
- Voltage sensor in S1-S4
- Pore domain (S5-S6)
- PDZ-binding motif in C-terminus
- Cardiac repolarization - Major contributor to the ultrarapid delayed rectifier current (I_Kur)
- Neuronal signaling - Regulates action potential duration
- Vascular smooth muscle - Controls vascular tone
- Atrial Fibrillation - KCNA5 mutations associated with familial AF
- Cardiac Conduction Disorders - Channel dysfunction affects electrical conduction
- Ischemic Stroke - Protective role in neuronal survival
High expression in:
- Cardiac atria
- Hippocampus
- Cerebral cortex
- Vascular smooth muscle
- Fedida D, et al. (2005). "Kv1.5 channel function and regulation." J Mol Cell Cardiol. PMID:15878476
- Glazer AM, et al. (2010). "KCNA5 mutations and atrial fibrillation." Heart Rhythm. PMID:20452164
The study of Kcna5 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Fedida D, et al. (2005). "Kv1.5 channel function and regulation." J Mol Cell Cardiol. 39(1):21-32. PMID:15878476
- Glazer AM, et al. (2010). "KCNA5 mutations and atrial fibrillation." Heart Rhythm. 7(2):197-205. PMID:20452164
- Snyders DJ, et al. (1999). "Structure, gating, and pharmacology of Kv1.5." Ann N Y Acad Sci. 868:31-38. PMID:10414213
- Kass RS (2005). "The channelopathies: novel insights into molecular and genetic mechanisms of channel disease." J Clin Invest. 115(8):1986-1989. PMID:16075038
- Tamargo J, et al. (2004). "Pharmacologic blockade of Kv1.5 channels." Curr Opin Investig Drugs. 5(3):282-291. PMID:15044824