KAT8 (Lysine Acetyltransferase 8), also known as MOF or MYST1, is a crucial histone acetyltransferase that primarily acetylates histone H4 at lysine 16 (H4K16ac). This modification is essential for chromatin decompaction and transcriptional activation.
| Property |
Value |
| Gene Symbol |
KAT8 |
| Gene Name |
Lysine Acetyltransferase 8 |
| Aliases |
MOF, MYST1, YBL026W |
| Chromosomal Location |
17q11.2 |
| NCBI Gene ID |
84144 |
| OMIM |
609912 |
| UniProt |
Q9H7Z6 |
| Ensembl |
ENSG00000103510 |
KAT8/MOF is a highly conserved histone acetyltransferase:
- Primary target: H4K16
- Also acetylates H4K5, H4K8
- Can acetylate H2AK5, H2BK120
KAT8 functions in multiple complexes:
- MSL (Male-Specific Lethal) complex
- NSL (Non-Specific Lethal) complex
- SAGA complex
H4K16 acetylation by KAT8:
- Prevents higher-order chromatin compaction
- Facilitates open chromatin configuration
- Enables transcription factor access
Essential for transcription regulation:
- Global transcription activation
- X-chromosome dosage compensation (in flies)
- DNA damage response
Critical for normal development:
- Embryogenesis
- Cell differentiation
- Organogenesis
KAT8 dysregulation in:
- Breast cancer
- Lung cancer
- Colorectal cancer
Potential involvement in:
- Intellectual disability
- Rett syndrome (related to Mecp2)
- Alzheimer's disease
KAT8/MOF is a critical histone H4K16 acetyltransferase essential for chromatin decompaction and transcription regulation.
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Daugeron et al., Nature Communications (2018)
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Kouzarides, Cell (2007)