| IL1RN | |
|---|---|
| Full Name | Interleukin 1 Receptor Antagonist |
| Chromosome | 2q14.1 |
| NCBI Gene ID | 3557 |
| Ensembl ID | ENSG00000136689 |
| OMIM ID | 147679 |
| UniProt ID | P18510 |
| Associated Diseases | Alzheimer's Disease, Neuroinflammation |
IL1RN (Interleukin 1 Receptor Antagonist) is a gene involved in neuronal survival, development, and function. The gene is located on chromosome 2q14.1.
IL1RN encodes a protein that plays important roles in the nervous system, including neuronal survival, differentiation, and synaptic plasticity.
Mutations or dysregulation of IL1RN are associated with several neurological disorders:
The gene is primarily expressed in:
Further research is needed to identify key publications for this gene.
IL1RN (Interleukin-1 Receptor Antagonist) encodes the IL-1 receptor antagonist (IL-1Ra), a naturally occurring protein that blocks the pro-inflammatory actions of IL-1α and IL-1β by competitively binding to the IL-1 receptor without triggering signal transduction. This protein is a crucial regulator of inflammation and is used therapeutically to treat inflammatory and autoimmune conditions.
IL-1Ra functions as:
IL-1Ra in AD:
Il1rn knockout mice:
| Drug | Type | Indication |
|---|---|---|
| Anakinra | IL-1Ra recombinant | RA, CAPS |
| Rilonacept | IL-1 Trap | CAPS |
| Canakinumab | Anti-IL-1β | CAPS, JIA |
IL1RN encodes the natural IL-1 receptor antagonist, a critical anti-inflammatory protein. By blocking IL-1 signaling, IL-1Ra protects against neuroinflammation in AD, PD, and stroke. Therapeutic IL-1Ra (Anakinra) is approved for inflammatory diseases with potential applications in neurodegeneration.
The study of Il1Rn — Interleukin 1 Receptor Antagonist has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.