HSPB10 (Heat Shock Protein Family B (Small) Member 10), also known as ODF1 (Outer Dense Fiber of Sperm Tail 1), is a gene that encodes a protein belonging to the small heat shock protein family. While primarily studied in the context of male fertility, emerging research suggests potential connections to cellular stress responses that may be relevant to neurodegenerative disease research. [1]
| Property | Value | [2]
|----------|-------| [3]
| Gene Symbol | HSPB10 | [4]
| Gene Name | Outer Dense Fiber of Sperm Tail 1 | [5]
| Aliases | ODF1, HSPB10, FLJ40598 | [6]
| Chromosomal Location | 8q22.3 |
| NCBI Gene ID | 4956 |
| OMIM | 608157 |
| UniProt | Q8WWI6 |
| Ensembl | ENSG00000147133 |
HSPB10 encodes a protein of approximately 341 amino acids with a molecular weight of approximately 30 kDa. The protein contains the characteristic alpha-crystallin domain shared by all small heat shock proteins (sHSPs), which is typically located in the C-terminal region and is involved in protein-protein interactions and chaperone activity [1].
The protein possesses several key structural elements:
HSPB10/ODF1 is primarily known for its role in sperm flagellar structure and function:
HSPB10 demonstrates highly tissue-specific expression:
While HSPB10 is not traditionally considered a neurodegeneration-related gene, several aspects of its biology may be relevant:
Heat shock proteins, including sHSPs, play important roles in protein homeostasis:
Although direct evidence is limited, the following connections may be relevant:
HSPB10 serves as a model system for understanding:
While HSPB10 is not currently a direct therapeutic target for neurodegenerative diseases, the broader sHSP family is of interest:
HSPB10 (ODF1) is a testis-specific small heat shock protein primarily known for its role in sperm flagellar structure and male fertility. While not a classical neurodegeneration gene, its function as a molecular chaperone and its involvement in protein homeostasis may provide insights into general mechanisms of cellular protection against protein aggregation and stress.
Zhang et al. Journal of Alzheimer's Disease (2020). 2020. ↩︎
Miesel & Kurpisz, Systems Biology in Reproductive Medicine (2015). 2015. ↩︎
Plastino et al. Andrologia (2020). 2020. ↩︎
Moretti et al. Journal of Molecular Histology (2016). 2016. ↩︎
Webster et al. BBA Proteins and Proteomics (2021). 2021. ↩︎