Gss Gene (Glutathione Synthetase) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Property | Value |
|---|---|
| Gene Symbol | GSS |
| Full Name | Glutathione Synthetase |
| Chromosomal Location | 20q11.22 |
| NCBI Gene ID | 2937 |
| OMIM ID | 601002 |
| Ensembl ID | ENSG00000100977 |
| UniProt ID | P16455 |
| Encoded Protein | Glutathione synthetase |
| Associated Diseases | 5-oxoprolinuria, neurodegeneration |
GSS is a gene involved in various cellular processes. The encoded protein plays important roles in metabolism, cellular signaling, and disease pathogenesis.
GSS encodes glutathione synthetase, the second enzyme in glutathione biosynthesis. GSS catalyzes the conversion of γ-glutamylcysteine to glutathione.
Key functions include:
GSS mutations cause 5-oxoprolinuria with:
GSS deficiency contributes to neurodegeneration through:
GSS is expressed in:
The study of Gss Gene (Glutathione Synthetase) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.