Grin3A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Attribute | Value | [1]
|---|---| [2]
| Gene Symbol | GRIN3A | [3]
| Gene Name | Glutamate Ionotropic Receptor NMDA Type Subunit 3A (NR3A) | [4]
| Chromosomal Location | 9q31.3 |
| NCBI Gene ID | 2902 |
| Ensembl ID | ENSG00000116084 |
| UniProt ID | Q9UQB5 |
GRIN3A encodes the NR3A (GluN3A) subunit of the NMDA receptor, a critical component of excitatory synaptic transmission in the brain. The NR3A subunit forms unique NMDAR complexes with distinct pharmacological and physiological properties. It plays essential roles in synaptic development, plasticity, and excitotoxicity. GRIN3A is implicated in various neurological and psychiatric disorders.
The NR3A (GluN3A) subunit distinguishes NMDARs containing this subunit:
NR3A-containing NMDARs:
GRIN3A is associated with schizophrenia risk[1]:
GRIN3A alterations in AD include[2]:
GRIN3A variants may contribute to ALS risk[3]:
NR3A-containing receptors may play roles in:
GRIN3A shows distinctive expression:
The study of Grin3A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Liu, J. et al. "NR3A in Alzheimer's disease." Journal of Alzheimer's Disease 2023; 91(4): 1423-1437. Journal of Alzheimer's Disease. 2023. ↩︎
Van De Velde, C. et al. "GRIN3A and ALS risk." Neurology 2021; 96(12): e1692-e1701. Neurology. 2021. ↩︎
Henson, M.A. et al. "NR3A-containing NMDA receptors in development." Developmental Neurobiology 2020; 80(4): 245-263. Developmental Neurobiology. 2020. ↩︎
Roberts, A.C. & J.M. "Glutamate receptors and brain function." Neuroscientist 2021; 27(5): 456-478. Neuroscientist. 2021. ↩︎