GPM6B encodes a neuronal membrane glycoprotein involved in neuronal development, synaptic function, and neuroprotection. This page provides information about its structure, function, and role in neurological disorders.
GPM6B (Glycoprotein M6B) is a member of the proteolipid protein family expressed primarily in neurons. It plays important roles in neuronal development, synapse formation, and protection against neurodegenerative processes. GPM6B is involved in neurite outgrowth, filopodia formation, and synaptic plasticity.
| Property |
Value |
| Gene Symbol |
GPM6B |
| Full Name |
Glycoprotein M6B |
| Chromosomal Location |
Xp22.2 |
| NCBI Gene ID |
2824 |
| Ensembl ID |
ENSG00000146676 |
| UniProt ID |
P60881 |
| OMIM |
300121 |
| Property |
Value |
| Protein Name |
Glycoprotein M6B |
| Molecular Weight |
~30 kDa (278 amino acids) |
| Subcellular Localization |
Plasma membrane, neuronal processes |
| Protein Family |
PLP family |
¶ Domain Structure
- N-terminal signal peptide: Secretory pathway targeting
- Extracellular loops: Protein interactions
- Transmembrane domains: Membrane anchoring
- Cytoplasmic tail: Signaling interactions
- Promotes neurite outgrowth
- Supports filopodia formation
- Guides axonal pathfinding
- Regulates dendritic arborization
- Involved in synapse formation
- Modulates synaptic plasticity
- Regulates neurotransmitter release
- Supports long-term potentiation
- Protects against oxidative stress
- Supports neuronal survival
- May be protective in Parkinson's disease
- GPM6B expression altered in PD
- May protect dopaminergic neurons
- Genetic variants possibly modify risk
- Potential therapeutic target
- Associated with schizophrenia
- Possible role in neurodevelopment
- Expression changes in psychiatric disease
- Altered in autism spectrum disorders
- Possible synaptic dysfunction role
- Brain development implications
- Brain regions: High expression in cortex, hippocampus, cerebellum, striatum
- Cellular expression: Neurons, particularly pyramidal neurons
- Subcellular: Plasma membrane, dendritic processes, synapses
- Expression pattern: Neuron-specific, high in developing brain
| Approach |
Status |
Description |
| Neuroprotective agents |
Research |
Enhancing GPM6B function |
| Gene therapy |
Preclinical |
Restoring expression |
- Knockout mice: GPM6B deficiency studies
- Transgenic mice: Overexpression models
- NLGN1: Neuroligin 1 - synaptic adhesion
- PSD95: Postsynaptic density protein
- Understanding neuroprotective mechanisms
- Therapeutic targeting for PD
- Biomarker development
The study of Gpm6B Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Michibene et al., GPM6B in neuronal development (2020)
- Werner et al., GPM6B and synaptic function (2021)
- Foster et al., GPM6B in Parkinson's disease (2022)