Glo1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Glo1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GLO1 (Glyoxalase 1) is a key enzyme in the methylglyoxal detoxification pathway. It plays important roles in protecting neurons from advanced glycation end products (AGEs) and oxidative stress, making it relevant to neurodegenerative diseases.
| Property | Value |
|---|---|
| Gene Symbol | GLO1 |
| Full Name | Glyoxalase 1 |
| Chromosomal Location | 6p25.2 |
| NCBI Gene ID | 2739 |
| OMIM ID | 138750 |
| Ensembl ID | ENSG00000124767 |
| UniProt ID | Q04760 |
GLO1 is a ~21 kDa metalloenzyme:
GLO1 performs critical detoxification functions:
| Brain Region | Expression Level |
|---|---|
| Hippocampus | Moderate |
| Cerebral Cortex | Moderate |
| Cerebellum | Moderate |
| Basal Ganglia | Moderate |
| Substantia Nigra | Moderate |
GLO1 is expressed in:
Glo1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Glo1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.