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| Symbol | EPHB2 |
| Full Name | Eph Receptor B2 |
| Chromosome | 1p36.12 |
| NCBI Gene | 2048 |
| OMIM | 600036 |
| Ensembl | ENSG00000199639 |
| UniProt | P29323 |
| Associated Diseases | Alzheimer's disease, ALS, deafness |
EPHB2 (Eph Receptor B2) is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication. As a receptor tyrosine kinase that binds ephrin-B ligands, EPHB2 regulates dendritic spine morphology, synaptic function, and neural circuit formation. Dysregulated EPHB2 signaling has been implicated in neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease.
EPHB2 is a key Eph receptor that regulates synaptic development, dendritic spine formation, and learning/memory. It binds ephrin-B ligands and mediates bidirectional signaling at synapses. EPHB2 is implicated in AD pathogenesis and synaptic loss.
High expression in hippocampus, cortex, and striatum.