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| Symbol | EPHB1 |
| Full Name | Eph Receptor B1 |
| Chromosome | 3p21.2 |
| NCBI Gene | 2047 |
| OMIM | 600011 |
| Ensembl | ENSG00000155090 |
| UniProt | P08620 |
| Associated Diseases | Brain development |
EPHB1 (Eph Receptor B1) is a member of the Eph receptor tyrosine kinase family that plays crucial roles in neural development, synaptic plasticity, and cellular communication. As a receptor tyrosine kinase that binds ephrin-B ligands, EPHB1 regulates dendritic spine morphology, synaptic function, and neural circuit formation. Dysregulated EPHB1 signaling has been implicated in neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease.
EPHB1 is a receptor tyrosine kinase that binds ephrin-B ligands. It regulates neuronal migration, axon guidance, and synaptogenesis.
Expressed in developing brain.