DLX6 encodes a homeobox transcription factor belonging to the Dlx family. It plays critical roles in embryonic development, particularly of the brain and craniofacial structures.
DLX6 is a transcription factor that regulates gene expression during development. It is involved in GABAergic neuron differentiation, olfactory bulb development, and forebrain patterning. DLX6 acts as part of a regulatory network with other DLX genes.
DLX6 and related DLX genes have been implicated in neurodevelopmental and neurodegenerative disorders. Altered DLX6 expression has been reported in Alzheimer's disease and Parkinson's disease. DLX6 is also involved in regulating genes important for dopaminergic neuron function.
DLX6 is expressed during embryonic development in the forebrain, particularly in the ventral telencephalon. In adult brain, expression is maintained in the olfactory bulb, cortex, and striatum.
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