Dlgap4 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Gene Symbol: DLGAP4
Full Name: DLG Associated Protein 4
Chromosomal Location: 8q22.3
NCBI Gene ID: 22858
OMIM: 616331
Ensembl ID: ENSG00000159788
UniProt ID: O75181
Associated Diseases: Cancer, Neurodevelopmental Disorders
DLGAP4 (DLG Associated Protein 4) is a member of the SAPAP family of postsynaptic density proteins. It participates in synaptic scaffolding and signal transduction at excitatory synapses. DLGAP4 interacts with PSD-95 and contributes to the organization of postsynaptic density complexes. It is expressed in various brain regions including the hippocampus and cortex. Beyond synaptic function, DLGAP4 has been implicated in cell polarity and division, with altered expression observed in certain cancers.
DLGAP4 is a member of the SAPAP family of postsynaptic density proteins. It participates in synaptic scaffolding and signal transduction at excitatory synapses. DLGAP4 interacts with PSD-95 and contributes to the organization of postsynaptic density complexes. It is expressed in various brain regions including the hippocampus and cortex. Beyond synaptic function, DLGAP4 has been implicated in cell polarity and division, with altered expression observed in certain cancers.
The DLGAP4 gene has been implicated in several neurodevelopmental and neurodegenerative disorders:
DLGAP4 is highly expressed in the brain, particularly in:
Expression is localized primarily to postsynaptic densities of excitatory synapses.
The study of Dlgap4 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.