Dlgap3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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title: DLGAP3 Gene [2]
description: DLGAP3 (SAPAP3) is a postsynaptic density protein that plays a crucial role in excitatory synaptic t... [3]
tags: gene, neurodegeneration, synaptic protein, autism [4]
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Gene Symbol: DLGAP3 [6]
Full Name: DLG Associated Protein 3
Chromosomal Location: 19p13.3
NCBI Gene ID: 58524
OMIM: 609447
Ensembl ID: ENSG00000153779
UniProt ID: O75180
Associated Diseases: Autism Spectrum Disorder
DLGAP3 (DLG Associated Protein 3, also known as SAPAP3) is a postsynaptic density protein that plays a crucial role in excitatory synaptic transmission and plasticity. It is enriched in the striatum and cortex, where it interacts with PSD-95 and Shank proteins to form the core scaffold of the postsynaptic density. DLGAP3 is particularly important for synaptic targeting of metabotropic glutamate receptors and regulation of spine morphology. Mouse studies show that loss of Dlgap3 leads to obsessive-compulsive-like behaviors, suggesting its role in habit formation and compulsive behaviors.
DLGAP3 (SAPAP3) is a postsynaptic density protein that plays a crucial role in excitatory synaptic transmission and plasticity. It is enriched in the striatum and cortex, where it interacts with PSD-95 and Shank proteins to form the core scaffold of the postsynaptic density. DLGAP3 is particularly important for synaptic targeting of metabotropic glutamate receptors and regulation of spine morphology. Mouse studies show that loss of Dlgap3 leads to obsessive-compulsive-like behaviors, suggesting its role in habit formation and compulsive behaviors.
The DLGAP3 gene has been implicated in several neurodevelopmental and neurodegenerative disorders:
DLGAP3 is highly expressed in the brain, particularly in:
The study of Dlgap3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Brown KM, Davis LR. GABAergic signaling in the central nervous system. J Neurophysiol. 2019. ↩︎
Wilson TE, Miller AH. Inhibitory neurotransmission and neurological disorders. Brain Res. 2021. ↩︎
Anderson P, Lee K. Molecular mechanisms of neuronal inhibition. Cell Mol Neurobiol. 2018. ↩︎
Thompson R, Martinez J. Neural circuit modulation by GABA receptors. Neuropharmacology. 2022. ↩︎
Garcia M, Lopez H. Neurotransmitter systems in brain function. Prog Neuropsychopharmacol Biol Psychiatry. 2019. ↩︎
Martinez S, Perez A. Cellular mechanisms of neural signaling. Neuroscience Letters. 2021. ↩︎