DAB1 encodes Disabled-1, an essential adaptor protein in the Reelin signaling pathway that controls neuronal migration and brain development. This page provides information about its structure, function, and role in neurological disorders. [1]
DAB1 (Disabled-1) is a key intracellular adaptor protein in the Reelin signaling pathway. The Reelin-DAB1 pathway is crucial for proper brain development, cortical layer formation, and synaptic plasticity. DAB1 mediates the effects of Reelin on neuronal positioning, dendrite maturation, and long-term potentiation. [2]
| Property | Value | [3]
|----------|-------| [4]
| Gene Symbol | DAB1 |
| Full Name | Disabled-1 |
| Chromosomal Location | 1p32-p31 |
| NCBI Gene ID | 1600 |
| Ensembl ID | ENSG00000170522 |
| UniProt ID | D3DX7A |
| OMIM | 603448 |
| Property | Value |
|---|---|
| Protein Name | Disabled-1 (DAB1) |
| Molecular Weight | ~80 kDa (625 amino acids) |
| Subcellular Localization | Cytoplasm, postsynaptic densities |
| Protein Family | Disabled family |
| Approach | Status | Description |
|---|---|---|
| Small molecule modulators | Research | Enhance Reelin-DAB1 signaling |
| Gene therapy | Preclinical | Restore DAB1 function |
| Peptide agonists | Research | Activate pathway |
The study of Dab1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Honda et al. DAB1 in brain development (2020). 2020. ↩︎
Frotscher et al. Reelin and DAB1 in synaptic plasticity (2019). 2019. ↩︎
Fatemi et al. DAB1 in neuropsychiatric disorders (2021). 2021. ↩︎
Hack et al. DAB1 phosphorylation and signaling (2018). 2018. ↩︎