Gene SymbolCXCL2
Full NameC-X-C Motif Chemokine Ligand 2 (Macrophage Inflammatory Protein 2)
Chromosomal Location4q21
Ensembl IDENSG00000024836
Associated DiseasesNeuroinflammation, Acute Lung Injury
The CXCL2 gene encodes macrophage inflammatory protein 2 (MIP-2), a C-X-C chemokine that acts as a potent neutrophil chemoattractant. Like CXCL1, CXCL2 signals through CXCR2 and plays critical roles in acute inflammation and tissue repair [1].
CXCL2 is rapidly induced by LPS and pro-inflammatory cytokines, particularly in neutrophils, macrophages, and fibroblasts [2].
CXCL2 functions as:
- Neutrophil Chemotaxis: Potent attractant for neutrophils
- Inflammatory Response: Amplifies inflammatory responses
- Angiogenesis: Promotes neovascularization
- Wound Healing: Important for tissue repair
- Neuroinflammation: Elevated in neuroinflammatory conditions
- Acute Lung Injury: Critical role in neutrophil recruitment
- Rheumatoid Arthritis: Contributes to joint inflammation
- Neutrophils: Primary source
- Macrophages: Induced by LPS and cytokines
- Brain: Microglial expression
- Brenchley et al., CXCL2/MIP-2 in inflammation (2006)
- Zlotnik et al., Chemokine networks (2006)
- Raman et al., CXCL2 in neuroinflammation (2011)
- O'Connor et al., CXC chemokines in brain injury (2005)
- Lee et al., CXCL2 and microglia (2008)
- Stadtmann et al., CXCR2 signaling (2015)
- Glass et al., Chemokine-mediated neurotoxicity (2010)
- Liu et al., CXCL2 in ALS (2016)