Csf2Ra — Colony Stimulating Factor 2 Receptor Alpha Chain is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| CSF2RA | |
|---|---|
| Colony Stimulating Factor 2 Receptor Alpha Chain | |
| Gene Symbol | CSF2RA |
| Full Name | Colony Stimulating Factor 2 Receptor Alpha Chain |
| Chromosome | Xp22.32 |
| NCBI Gene ID | 1442 |
| Ensembl ID | ENSG00000198211 |
| OMIM | 306010 |
| UniProt ID | P15509 |
| Associated Diseases | Multiple Sclerosis, Alzheimer's Disease, Parkinson's Disease |
| Expression | Hematopoietic cells, Microglia, Macrophages, Neurons |
CSF2RA (Colony Stimulating Factor 2 Receptor Alpha Chain) encodes the alpha chain of the GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) receptor. This receptor is a heterodimer consisting of a ligand-specific alpha chain (CSF2RA) and a common beta chain (CSF2RB) that is shared with the IL-3 and IL-5 receptors.
The GM-CSF receptor mediates signaling for cell proliferation and differentiation:
The study of Csf2Ra — Colony Stimulating Factor 2 Receptor Alpha Chain has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.