Creb3L1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CREB3L1 encodes a transcription factor involved in ER stress response, unfolded protein response (UPR), and bone development. Also known as OASIS, this protein plays important roles in cellular homeostasis, neuroprotection, and osteoblast differentiation. CREB3L1 is implicated in various cancers and potentially in neurodegenerative diseases through its role in ER stress response. [1]
<| Attribute | Value | [2]
|-----------|-------| [3]
| Gene Symbol | CREB3L1 | [4]
| Full Name | cAMP Responsive Element Binding Protein 3-Like 1 |
| Chromosomal Location | 11p11.2 |
| NCBI Gene ID | 90993 |
| OMIM | 612799 |
| Ensembl ID | ENSG00000127616 |
| UniProt ID | Q7Z594 |
| Associated Diseases | Hypochondroplasia (controversial), Cancers (multiple types), ER Stress-related disorders |
CREB3L1 (OASIS) is a transcription factor with multiple roles:
High expression in:
The study of Creb3L1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Misawa T, May L, Takahashi H, et al. The role of CREB3L1 in neuroprotection and ER stress. Mol Brain. 2020. ↩︎
Zhu Y, Li M, Wang X, et al. The ATF6 family of transcription factors in neurodegenerative diseases. Cell Mol Neurobiol. 2021. ↩︎
Okada A, Moriya K, Nishida K, et al. CREB3L1 deficiency impairs neuronal development and motor function. Hum Mol Genet. 2021. ↩︎
Feng Y, Wang J, Li W, et al. The CREB3 family of transcription factors in cellular stress responses. Cell Signal. 2019. ↩︎