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| Symbol | CHRM5 |
| Full Name | Cholinergic Receptor Muscarinic 5 |
| Chromosome | 15q26.1 |
| NCBI Gene | 1133 |
| OMIM | 118526 |
| Ensembl | ENSG00000151012 |
| UniProt | P47895 |
| Associated Diseases | Reward, addiction |
CHRM5 (Cholinergic Receptor Muscarinic 5) is a muscarinic acetylcholine receptor that mediates cholinergic signaling in the central and peripheral nervous systems. Muscarinic receptors are G protein-coupled receptors that regulate various neuronal functions including cognition, memory, and motor control. Dysregulated CHRM5 signaling has been implicated in neurodegenerative diseases including Alzheimer's disease.
CHRM5 encodes the M5 muscarinic acetylcholine receptor. It is expressed in reward pathways and may be involved in addiction.
Expressed in VTA, nucleus accumbens, and cortex.