Ccl3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CCL3 (Chemokine C-C Motif Ligand 3), also known as MIP-1α (Macrophage Inflammatory Protein-1 alpha), encodes a CC chemokine that plays important roles in inflammation, immune cell recruitment, and neuroinflammation. It is implicated in the pathogenesis of various neurodegenerative diseases. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Gene Symbol | CCL3 | [4]
| Gene Name | Chemokine C-C Motif Ligand 3 |
| Chromosomal Location | 17q12 |
| Ensembl ID | ENSG00000108175 |
| OMIM ID | 182283 |
| UniProt ID | P10147 |
| Also Known As | MIP-1α, LD78β |
CCL3 is a 99-amino acid protein that belongs to the CC chemokine family. It is secreted as a mature protein following signal peptide cleavage.
CCL3 is expressed in various cell types including:
CCL3 (MIP-1α) is expressed in various cell types:
CCL3 plays complex roles in neurodegeneration:
The study of Ccl3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.