Camkk2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CAMKK2 encodes calcium/calmodulin-dependent protein kinase kinase 2, an upstream kinase that activates AMPK and CaMK1 in response to calcium signaling. The enzyme plays critical roles in neuronal calcium signaling, synaptic plasticity, metabolism regulation, and cell survival. CAMKK2 is implicated in Alzheimer's disease, metabolic disorders, and cancer. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Gene Symbol | CAMKK2 | [4]
| Full Name | Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 |
| Chromosomal Location | 12q24.13 |
| NCBI Gene ID | 8146 |
| OMIM | 615092 |
| Ensembl ID | ENSG00000110939 |
| UniProt ID | Q96HS5 |
| Associated Diseases | Alzheimer's Disease, Metabolic Syndrome, Cancer |
CAMKK2 is a serine/threonine protein kinase:
High expression in:
The study of Camkk2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Marcelo KL, Means AR, York B. The Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) pathway. Adv Biol Regul. 2016. ↩︎
Nicovich PR, Gaur R, Aronica C, et al. The role of CAMKK2 in neuronal function and disease. Mol Brain. 2021. ↩︎
Wei C, Wang Z, Zhou Z, et al. CaMKK2 as a potential therapeutic target in Alzheimer's disease. Transl Neurodegener. 2022. ↩︎
Liu X, Niu W, Liu Y, et al. CAMKK2 regulates synaptic plasticity and cognitive function. J Neurosci Res. 2019. ↩︎