Aldh1A2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| ALDH1A2 | |
|---|---|
| Gene Symbol | ALDH1A2 |
| Full Name | Aldehyde Dehydrogenase 1 Family Member A2 |
| Chromosomal Location | 15q21.2 |
| NCBI Gene ID | 8854 |
| OMIM ID | 603687 |
| Ensembl ID | ENSG00000128918 |
| UniProt ID | O00469 |
| Encoded Protein | Retinaldehyde Dehydrogenase 2 |
| Associated Diseases | Retinitis Pigmentosa, Parkinson's Disease, Neurodegeneration |
The ALDH1A2 gene encodes Retinaldehyde Dehydrogenase 2, a protein involved in aldehyde dehydrogenase 1 family member a2.
Aldehyde Dehydrogenase 1 Family Member A2 plays critical roles in cellular processes including:
ALDH1A2 mutations or dysregulation are associated with retinitis pigmentosa, contributing to disease pathogenesis through various mechanisms including protein aggregation, signaling dysregulation, and cellular stress responses.
ALDH1A2 is expressed in multiple brain regions with highest expression in:
The study of Aldh1A2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.